Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease
نویسندگان
چکیده
منابع مشابه
Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.
A20 [also known as TNFAIP3 (tumour necrosis factor α-induced protein 3)] restricts and terminates inflammatory responses through modulation of the ubiquitination status of central components in NF-κB (nuclear factor κB), IRF3 (interferon regulatory factor 3) and apoptosis signalling cascades. The phenotype of mice with full or conditional A20 deletion illustrates that A20 expression is essentia...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2011
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst0391086